By Lance Stewart, Ph.D., MBA
What do Dave Duerson, Gabrielle Giffords, Zachery Lystedt, the “Afghanistan Shooter” Robert Bales, and Jackson Stewart all have in common?
They all suffered Traumatic Brain Injury (TBI).
On August 8, 2011, my family was thrust into a steep learning curve of TBI.
My son Jackson was 18 at the time, [...]
Traumatic brain injury (TBI) is a significant health problem in the United States. The Centers for Disease Control and Prevention (CDC) estimates that 1.7 million people sustain traumatic brain injury in the United States each year; 52,000 die; 275,000 are hospitalized; and 1.4 million, nearly 80%, are treated and released from an emergency [...]
Conventional drug discovery strategies have had very little success at finding small molecules that can potently disrupt protein-protein interactions which underlie the assembly or regulation of large, multi-protein complexes. This is because the interaction surfaces are large, frequently flat, and therefore lack binding elements for small molecules that can effectively inhibit binding of a protein [...]
Why make allosteric modulators of PDE4? There are four PDE4 genes in mammals (PDE4A-B) and each gene encodes multiple transcripts. PDE4 splice isoforms are grouped as “long”, “short” and “super-short” based on their N-terminal sequence. All splice isoforms contain the UCR2 regulatory domain as shown in the cartoon.
Twitter Updates from Lance Stewart