This month Dr. Mark Gurney was named as one of two leading inventors in the field of Alzheimer’s disease treatments in Clearing the Fog by Ambercite, he is directly mentioned on page 20 of the report.
Clearing the Fog is an analysis of roughly 48,000 patents on treatments for Alzheimer’s disease. Network Path analysis was used to [...]
As a young woman, Stacey Plax was thrown from a jeep while on a group tour in Israel. Stacey made a remarkable recovery from her traumatic brain injury. At left is Stacey today, revisiting the Judean desert. This is her story.
In 1998, when I was sixteen, it [...]
By Lance Stewart, Ph.D., MBA
What do Dave Duerson, Gabrielle Giffords, Zachery Lystedt, the “Afghanistan Shooter” Robert Bales, and Jackson Stewart all have in common?
They all suffered Traumatic Brain Injury (TBI).
On August 8, 2011, my family was thrust into a steep learning curve of TBI.
My son Jackson was 18 at the time, [...]
When Michigan’s lakes ice over in winter, Randy Rogoski can be found sailing his iceboat. His 12-foot-long DN can sail 55 mph. Fortunately, he wasn’t going that fast when he crashed on December 26, 2010, and landed on his head. Rogoski never sails his iceboat without wearing a helmet, but that day it did [...]
Traumatic brain injury (TBI) is a significant health problem in the United States. The Centers for Disease Control and Prevention (CDC) estimates that 1.7 million people sustain traumatic brain injury in the United States each year; 52,000 die; 275,000 are hospitalized; and 1.4 million, nearly 80%, are treated and released from an emergency [...]
Conventional drug discovery strategies have had very little success at finding small molecules that can potently disrupt protein-protein interactions which underlie the assembly or regulation of large, multi-protein complexes. This is because the interaction surfaces are large, frequently flat, and therefore lack binding elements for small molecules that can effectively inhibit binding of a protein [...]
Why make allosteric modulators of PDE4? There are four PDE4 genes in mammals (PDE4A-B) and each gene encodes multiple transcripts. PDE4 splice isoforms are grouped as “long”, “short” and “super-short” based on their N-terminal sequence. All splice isoforms contain the UCR2 regulatory domain as shown in the cartoon.
Twitter Updates from Lance Stewart