Tetra Discovery Partners LLC is a leader is the chemical design of inhibitors of phosphodiesterase (PDE) enzymes.  In the brain, PDEs are involved in cognition/memory, schizophrenia, depression and neuroinflammation. Tetra uses a structure-guided drug design chemistry approach to discover mechanistically novel, allosteric inhibitors of phosphodiesterase 4 (PDE4) subtypes such as PDE4B and PDE4D.

Tetra is targeting the function of PDE4s, to enhance memory formation in brain neurons, nerve dendrites involved in schizophrenia and depression, and brain microglia involved in brain inflammation. Tetra’s drug discovery platform can also be used to develop novel treatments for peripheral diseases where PDEs are attractive drug targets.


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